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The National Institute for Occupational Safety and Health (NIOSH) initiated a research-based prevention program in agricultural safety and health in 1990, and part of that program focuses on hazards associated with tractors. The program incorporates both intramural and extramural components and includes three principal elements: surveillance, research, and intervention. This program has improved the characterization of tractor-related hazards, increased knowledge about using roll-over protective structures (ROPS), and disseminated information as a strategy to prevent tractor-related injuries. NIOSH has identified machine-related injuries as a priority area, which includes preventing tractor-related injuries. In addition, the Department of Health and Human Services, of which NIOSH is a part, is considering a national objective to promote the installation of a ROPS on every tractor used in agricultural production.