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The efficacy of a commercial ozonation system for reduction of odors was studied. In this system ozone was distributed throughout the animal housing facility using a manifold. In this study the VOCs in the air and the odor of the air were monitored. The VOCs were measured using thermal desorption tubes and SPME fibers with PDMS/CAR coatings. Ozone was effective in reducing odor detection threshold, but did not significantly reduce the odor intensity or odor offensiveness in the building. Sensory testing indicated that the characteristics of the air in the ozonated rooms were different from those in control room. Monitoring of the VOCs present in the air showed that ozonation reduced the levels of phenolic and indolic compounds in the swine building air, however, it did not reduce the level of volatile fatty acids in the air.