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The subject of this paper is the application of computational fluid dynamics (CFD) for the modelling of the internal climate of a commercial multi-span Venlo-type glasshouse containing tomato crops. The step-by-step process to build a comprehensive glasshouse model is summarised and examples of typical results are presented. A good agreement of predictions with available experimental data was found. Along with the latest results from the authors leading edge research programme, the aim of which is the development of a fully three-dimensional model of a full-scale commercial multi-span Venlo-type glasshouse, the future of CFD in glasshouse research is briefly discussed.