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The identification of waterbodies not meeting their designated use and the development of total maximum daily loads (TMDLs) for those waterbodies are required by Section 303(d) of the Clean Water Act and the Environmental Protection Agencys Water Quality Planning and Management Regulations. The Mississippi Department of Environmental Quality (MDEQ) has identified a segment of Indian Creek as being impaired for a total length of 3 miles as reported in the Mississippi 1998 Section 303(d) List of Waterbodies. Subsequently, a TMDL for Indian Creek has been developed for total ultimate biochemical oxygen demand, based on the applicable state standard for dissolved oxygen. A mathematical model for DO distribution in streams, QUAL2E, was selected as the model for determining the TMDL for Indian Creek. The model was calibrated using data that were collected during an intensive study of Indian Creek conducted by MDEQ in August and September 1998. The TMDL consists of a wasteload allocation due to point sources and a load allocation due to nonpoint sources of TBODU. Results of the TMDL indicate that the existing load of oxygen demanding material exceeds the assimilative capacity of the creek. Thus, a commensurate reduction has been recommended by this TMDL.