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Microencapsulation of bioactive compounds obtained from pitahaya and soya for possible use as a dietary supplement in menopause.

Published by the American Society of Agricultural and Biological Engineers, St. Joseph, Michigan

Citation:  2021 ASABE Annual International Virtual Meeting  2100209.(doi:10.13031/aim.202100209)
Authors:   Everardo Mares-Mares, Paola Elizabeth Iwinski-Hernández, Ignacio Alberto Vallejo-Gonzalez, Luis Armando Garcia de la Rosa, Ma. Cristina Del Rincón-Castro, Maria Azucena Rocha-Mendoza
Keywords:   Antioxidant, Menopause, Microencapsulated, Pitahaya, soybean-isoflavones.

Abstract. During menopause stage, women are affected by several symptoms such as hot flashes, mood swings, vaginal dryness, among others. Unfortunately, current treatments are aggressive, as they can lead to side effects besides of the lack of alternatives such as dietary supplements for their treatment. The objective of this work is to obtain a dietary supplement that diminishes the effects of menopause and to be of natural origin, using the microencapsulation technology of soy isoflavones (as a source of phytoestrogens) and antioxidants of pitahaya shell (phenolic and anthocyanin compounds), as a little-known source of antioxidants. A methodology is designed for sequential methanol extraction of soybean isoflavones in combination with the extraction of phenolic compounds and anthocyanins from pitahaya shell. The free-of-methanol mixed extract was mixed with maltodextrin to be microencapsulated by spray drying, using a box-behnken response surface design. Performance, efficiency, load and morphology of the MEB microencapsulated were evaluated. Spray drying encapsulation conditions according to the optimized model were 120°C inlet temperature, 1:9 extract-maltodextrin (w/w) ratio and 5mL/min feed. Encapsulation yield of 59.54% was obtained. With respect to microencapsulate, isoflavones total load of 0.71mg/g, phenolic compound content of 3,046mg E.A.G/g and 179.98mg of cyanidin 3 glycoside/g were obtained. According to the MEB, microcapsules with irregular shape, surface contracted with folds and microcapsules that have a spherical shape with smooth but cracked surface and with an average diameter of 14.34μm were observed. In this first phase of the project, the microencapsulation conditions for bioactive compounds of soybeans and pitahaya shell have been established in order to maintain their biological activity due to their sensitivity to extrinsic factors. However, it is necessary to perform an in vitro analysis of the antioxidant activity to determine its potential as a dietary supplement for menopause treatment.

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