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Anaerobic co-digestion of swine manure and corn stover for biogas production has been studied in completely-mixed and semi-continuously fed reactors. Preliminary results indicate that corn stover has been substantially degraded to methane in anaerobic co-digestion with swine manure. Corn stover contains mainly cellulose, hemicelluloses, and lignin, so cellulose-degrading microorganisms must have played an important role in the anaerobic co-digestion. One of the main objectives of this study was to analyze the cellulose-degrading microorganisms and their activities in the digestion.