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The dose and the protection effect of pesticide are directly affected by the pesticide droplet size. Too Large droplet size can result in increasing the dose of pesticide or failing to reach the protection effect, too small droplet size can increase the drift. In this paper, axial air-blast rotating cage sprayer was used, besides, the characteristic variable parameters include three types of cage diameter 80, 100, 120mm, three kinds of cage mesh number 60,120,180, three kinds of cage speed 3000, 4000, 5000rpm, and three kinds of liquid flow 40, 60, 80L/h. Regardless of the characteristic parameters conditions, the flow had little effect on droplet size, on the condition of cage diameter of 80mm, cage rotating speed of 3000rpm, cage mesh number of 80, the corresponding droplet volume diameters (VMD) are respectively 165.4, 165.2, 166.2um under the flows 40, 60, 80L/h; on the condition of mesh number of 120, the cage diameter of 100mm, speed of 4000 rpm, VMD are respectively 129.3, 127.5, 126.5um under the flow of 40, 60, 80L/h. Droplet diameter decreases with the increase of cage rotating speed. When mesh number is 60, the cage diameter is 80mm, and the flow is 40L / h, the rotating speed ranged from 3000rpm to 5000rpm, and then the corresponding droplet diameters shrank from 165.4um to 127.5um. The droplet diameter was little influenced by the number of cage mesh and the cage diameter. The droplet diameter decreased slightly with the increase of the mesh number and the cage diameter. When the mesh number changed from 60 to 180, the droplet diameter only decreased from 142.7um to 127.5um, on the corresponding condition of cage diameter of 80mm, flow of 40L/h, speed of 4000rpm. Cage diameter increases from 80mm to 120mm, and the droplet diameter decreased from 142.7um to 122.4um, on condition of mesh number of 60, flow of 40L / h, speed of 4000rpm .The results showed that the droplet diameter was mainly influenced by the cage rotating speed, the cage diameter and mesh number were another factors, and the flow rate can hardly have impact on the droplet diameter. Regardless of any variable conditions, the droplet diameter formed by rotating cage sprayer is smaller than the normal one. In addition, the air-blasted droplets were transmitted to the target domain, which can effectively improve the using efficiency of pesticide, and yet decrease the dose of pesticide use and the drift.