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Bio-oil was obtained by co-deoxy-liquefaction of swine manure and waste vegetable oil in the work. Results show the weight ratio of swine manure to waste vegetable oil exerted a great effect on both the yield and quality of the obtained bio-oil. The optimum weight ratio of swine manure to waste cooking oil was 1:3, where a maximum oil yield of 80% was obtained with higher calorific value up to 38 MJ/kg. The overall efficiency of the deoxy-liquefaction of swine manure and decarboxylation of waste vegetable oil were both enhanced by adding waste vegetable oil into swine manure.