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The Comprehensive Economic and Environmental Optimization Tool Macro Modeling System (CEEOT-MMS) was developed recently by researchers at the Texas Institute for Applied Environmental Research (TIAER) to help evaluate the implementation of agro-environmental policies or practices on large scales. CEEOT-MMS consists of a field-scale environmental model and a farm-level economic simulation model. Recently, CEEOT-MMS was applied to evaluate the impacts of alternative manure nutrient management options when implemented on all animal feeding operations (AFOs) in Texas. The model was also applied to study the impacts of changing herd sizes on the efficacy of various nutrient management practices, as well as the costs and effectiveness of implementing comprehensive nutrient management plans (CNMPs) on AFOs.