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Cyclones are commonly used in the processing industry as primary particulate emissions abatement devices. A study was conducted to evaluate the effectiveness of one, two, three, or four 1D3D cyclones, in series, on airstreams heavily loaded (236 g/m3) with fine particulate (mass median diameter <10 m). The overall efficiency of a single cyclone (91%) was significantly lower than that of the series cyclone configurations (98%). Also, a single cyclone was consistently less efficient (91%) and had a higher static pressure loss (1356 Pa[5.4 in. w.g.]) than the No. 1 cyclone in the series configurations (94% efficiency and 881 Pa [3.5 in. w.g.] static pressure loss). Particle size distributions showed that there was a significant shift toward smaller sized particles in dust captured by the cyclones (8.78 to 1.86 m) as the number of series cyclones increased from one to four. A secondary cyclone increased overall efficiency significantly with an insignificant rise in static pressure loss, while additional cyclones raised efficiency only about 1% more and increased pressure losses by 150%.