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Confined manure storage entry is identified as a major safety concern in the agricultural industry. Oxygen-deficient atmospheres as well as toxic and/or explosive gases (e.g., NH3, H2S, CH4 and CO2) coming from fermentation and agitation may create very hazardous conditions to farmers who may need to enter these confined manure storages to work or perform maintenance. The goal of the research is to develop effective ventilation design recommendations for confined manure storages to reduce the risk coming from entry into confined manure storage facilities. The research is divided into two phases: experimental screening of ventilation strategies and Computational Fluid Dynamic (CFD) model simulation for effective ventilation design recommendations. Adequate experimental data for NH3 and H2S concentrations during ventilation have been collected to identify the most promising candidate ventilation strategies. Meanwhile, preliminary measurements of gas emission rate from manure during agitation and during ventilation after agitations are being conducted. The identified ventilation strategies and the measured emission rates obtained will be used to set up CFD simulations. The experimental data will be applied to validate and verify the CFD model.