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Particulate matter and gaseous pollutants produced in animal buildings have an adverse effect on health and comfort of workers and animals, and are also cause of concern to the people living close to animal buildings when emitted to the ambient environment. This paper summarized recent developments on aerodynamic air cleaning technology for particulate matter and gas emission control. Reverse flow cyclones are centrifugal separators that are widely used for industrial particulate matter removal. Typical pressure drops of these cyclones for air cleaning are 500 Pa or higher, and were believed to be only able to separate particles larger than 10 m. An aerodynamic deduster that was able to separate particles as small as 3 m at a pressure drop of 100 Pa was developed by the authors group. Unlike the existing cyclone technology, the deduster used a low pressure and low turbulent approach to substantially minimize the particle reentrainment and enhance the particle separation efficiency. By combining a fine mist scrubbing section, where gas absorption and particle coagulation took place, the deduster reduced ammonia emission by as much as 84% at low liquid/gas flow ratio. The airflow rate capacity of different deduster designs were between 135 to 12,000 L/s. Both laboratory and field evaluations showed that the deduster can be effectively used in reducing particulate matter emission from stationary sources.