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A facility to expose human subjects to odorous, dusty air from a swine building, which is diluted with filtered, clean air, was developed. This paper describes the facility design, including exposure room, air handling and measurement, medical evaluation annex, HVAC, air filtration, and mixing chamber, as well as approaches which allow complete cleaning of interior surfaces between exposure trials. Methods of measuring human irritation, to characterize shortterm health effects associated with the exposures, are also described.